3-Methoxyphencyclidine\u00a0(3-MeO) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like PCP, MXE, and 3-MeO-PCE for sale online.buy 3-meo-pcp online<\/p>\n
3-MeO-PCP for sale online,it\u00a0 was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to PCP along with comparable potency.<\/p>\n
Like other substances of its class, particularly methoxetamine (MXE), phencyclidine (PCP), and\u00a03-MeO-PCE, it is known to primarily induce a state referred to as \u201cdissociative anesthesia\u201d, although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken orally and nasally, although it may also be smoked and injected. It has been noted for its subtle come up and tendency to produce delusions of sobriety, which can lead to compulsive redosing.<\/p>\n
Today, 3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area\u00a0research chemical\u00a0through the use of online vendors, where it is commonly used as a recreational substance and, more rarely and controversially, as an entheogen. Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if using this substance.<\/p>\n
3-MeO-PCP has a Ki of 20 nM for the dizocilpine (MK-801) site of the NMDA receptor, 216 nM for theserotonin transporter (SERT), and 42 nM for the sigma \u03c31 receptor.It does not bind to the norepinephrine or dopamine transporter nor to the sigma \u03c32 receptor (Ki >10,000 nM).Based on its structural similarity to 3-hydroxy-PCP (3-HO-PCP), which uniquely among arylcyclohexylamines has high affinity for the \u03bc-opioid receptor in addition to the NMDA receptor, it was initially expected that 3-MeO-PCP would have opioid activity. However, radioligand binding assays with human proteins have shown that, contrary to common belief, the drug also does not interact with the \u03bc-, \u03b4-, or \u03ba-opioid receptors at concentrations of up to 10,000 nM. As such, the notion that 3-MeO-PCP has opioid activity has been described as a myth.3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions of PCP, followed by 2-MeO-PCP and 4-MeO-PCP.<\/p>\n
Buy 3-Methoxyphencyclidine online, or 3-MeO-PCP, is a synthetic dissociative of the arylcyclohexylamine class. 3-MeO-PCP contains cyclohexane, a six-member saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a methoxy group.3-MeO-PCP for sale online,it is a PCP derivative and structurally analogous to 4-MeO-PCP.<\/p>\n","protected":false},"excerpt":{"rendered":"
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